Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.85 |
| ▸ | MEN1 | O00255 | 4/20 | 0.85 |
| ▸ | RECQL | P46063 | 4/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.85 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.85 |
| ▸ | BLM | P54132 | 3/20 | 0.85 |
| ▸ | MAOA | P21397 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | GAA | P10253 | 2/20 | 0.85 |
| ▸ | ESR1 | P03372 | 2/20 | 0.85 |
| ▸ | MGAM | O43451 | 1/20 | 0.85 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | GLA | P06280 | 1/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | THRB | P10828 | 1/20 | 0.85 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.85 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006760 | 1.00 | KDM4E (0.85) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL30004934 | 1.00 | KDM4E (0.85) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL15870371 | 1.00 | KDM4E (0.85) | KDM4EMAPTMEN1RECQLKMT2A | |
| Coumestrol SCHEMBL22012 | 0.92 | ESR2 (1.00) | KDM4EMAPTMEN1RECQLKMT2A | |
| Coumestrol SCHEMBL29453366 | 0.92 | ESR2 (1.00) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL15870374 | 0.88 | ESR2 (0.84) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL15864245 | 0.85 | KDM4E (0.70) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL30602583 | 0.85 | KDM4E (0.70) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL30482848 | 0.85 | KDM4E (0.70) | KDM4EMAPTMEN1RECQLKMT2A | |
| SCHEMBL14177143 | 0.84 | ESR1 (0.82) | KDM4EMAPTMEN1RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | claimed |
| EP-2346844-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | Council Of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010052734-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | claimed |
| EP-2346844-B1 | SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL SCIENT IND RES (IN) | 2017-09-20 | — | — | EP | disclosed |
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | BG NEGEV TECHNOLOGIES & APPLIC LTD (IL) | 2015-11-26 | — | — | US | disclosed |
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | BG NEGEV TECHNOLOGIES & APPLIC LTD (IL) | 2015-11-26 | — | — | US | disclosed |
| WO-2014106848-A1 | COUMESTAN, COUMESTROL, COUMESTAN DERIVATIVES AND PROCESSES OF MAKING THE SAME AND USES OF SAME | B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. (IL) | 2014-07-10 | — | — | WO | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| EP-2346844-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | Council Of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010052734-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | CYP19A1, ESR1, GPER1 | KDM4E 880/4885MAPT 1557/4885MEN1 954/4885 |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | AKR1C3, AKR1C4, SLC10A1 | KDM4E 2194/4885MAPT 4821/4885MEN1 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.