Coumestrol

Coumestrol

SCHEMBL22012

O=c1oc2cc(O)ccc2c2oc3cc(O)ccc3c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 6/20 1.00
ESR1 P03372 5/20 1.00
KDM4E B2RXH2 3/20 1.00
MAPT P10636 3/20 1.00
MEN1 O00255 2/20 1.00
GAA P10253 2/20 1.00
HPGD P15428 2/20 1.00
RECQL P46063 2/20 1.00
BLM P54132 2/20 1.00
KMT2A Q03164 2/20 1.00
ALDH1A1 P00352 2/20 1.00
LMNA P02545 2/20 1.00
MGAM O43451 1/20 1.00
NR1I2 O75469 1/20 1.00
GLA P06280 1/20 1.00
POLB P06746 1/20 1.00
THRB P10828 1/20 1.00
CSNK2A2 P19784 1/20 1.00
MAOA P21397 1/20 1.00
CSNK2B P67870 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Coumestrol SCHEMBL29453366 1.00 ESR2 (1.00) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL30006760 0.92 KDM4E (0.85) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL15870371 0.92 KDM4E (0.85) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL30004934 0.92 KDM4E (0.85) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL234819 0.92 KDM4E (0.85) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL15870374 0.92 ESR2 (0.84) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL14177143 0.91 ESR1 (0.82) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL15870375 0.90 KMT2A (0.82) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL30266809 0.87 MAPT (0.76) ESR2ESR1KDM4EMAPTMEN1
SCHEMBL4778019 0.87 MAPT (0.76) ESR2ESR1KDM4EMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3709 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107510-A1 HOT-MELT ADHESIVE COMPOSITION AND METHOD OF APPLICATION BIOBOND ADHESIVES, INC. (US) 2026-05-21 WO claimed
US-20260130395-A1 Water Dispersible Botanical Compositions AQUILA BLACK LTD (AU) 2026-05-14 US claimed
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS Nuchido Limited (GB) 2026-04-02 US claimed
EP-3485726-B1 CULTURING METHOD FOR CULTURED LEGUMINOUS ROOTS HAVING INCREASED COUMESTROL CONTENT AMOREPACIFIC CORP (KR) 2026-03-25 EP claimed
EP-3346842-B1 STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME NOVONESIS PLANT BIOSOLUTIONS AS (DK) 2026-03-25 EP claimed
US-12569422-B2 Composition and method of inhibiting cortisone reductase by applying it to the skin AMOREPACIFIC CORPORATION (KR) 2026-03-10 US claimed
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP claimed
WO-2025125889-A1 PREGNANE X RECEPTOR (PXR) ANTAGONISTS FOR THE TREATMENT OF DENGUE FEVER CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL I.P.N. (MX) 2025-06-19 WO claimed
EP-4101437-B1 BACTERIOSTATIC COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF SHENZHEN EULIKAN BIOTECHNOLOGY CO LTD (CN) 2025-06-11 EP claimed
US-20250170166-A1 HYALURONIC ACID HYDROGEL FORMULATION COMPRISING PHYTOESTROGEN FOR THE TREATMENT OF VAGINAL ATROPHY AND VAGINAL REJUVENATION AND PRODUCTION METHOD THEREOF VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI (TR) 2025-05-29 US claimed
WO-1998021946-A1 COMPOSITION AND TREATMENT FOR PERSISTENT REPRODUCTIVE TRANSITION SYMPTOMS INTERNUTRIA, INC. (US) 1998-05-28 WO claimed
WO-1998019166-A1 NON RADIOACTIVE RECEPTOR ASSAY SUITABLE FOR QUANTITATIVE AND QUALITATIVE ANALYSIS OF TRACE AMOUNTS OF RECEPTOR BINDING ANALYTE ELIMO B.V. (NL) 1998-05-07 WO claimed
EP-0821790-A1 ON-LINE COUPLING OF BIOCHEMICAL DETECTION TO CONTINUOUS-FLOW SEPARATION TECHNIQUES Rijksuniversiteit te Leiden (NL) 1998-02-04 EP claimed
US-5569459-A ADMINISTERING ONE OR MORE PHYTOESTROGENS, LICORICE ROOT EXTRACT, BETA-CAROTENE, PYROXIDINE HYDROCHLORIDE, VITAMIN E, CALCIUM, MAGNESIUM AND ZINC SALTS, COUMESTAN AND PANTOTHENIC ACID BIO-VIRUS RESEARCH INCORPORATED (US) 1996-10-29 US claimed
WO-1996033409-A1 ON-LINE COUPLING OF BIOCHEMICAL DETECTION TO CONTINUOUS-FLOW SEPARATION TECHNIQUES RIJKSUNIVERSITEIT TE LEIDEN (NL) 1996-10-24 WO claimed
WO-1996033408-A1 ON-LINE COUPLING OF BIOCHEMICAL DETECTION TO CONTINUOUS-FLOW SEPARATION TECHNIQUES RIJKSUNIVERSITEIT LEIDEN (NL) 1996-10-24 WO claimed
US-5424331-A Phytoestrogen compounds, dried licorice root extract, a calcium salt, a mgnesium salt, a zinc salt, beta-carotene, Vitamin D and Vitamin E BIO-VIRUS RESEARCH INCORPORATED (US) 1995-06-13 US claimed
US-5277910-A Extracting the seed, root, stalk or leaves of alfalfa HIDVEGI MATE (HU) 1994-01-11 US claimed
US-5229113-A Gene expression, soybeans LUBRIZOL GENETICS, INC. (US) 1993-07-20 US claimed
CN-1074123-A Method for preparing pharmaceutical composition for selectively reducing blood lipid level MATE HIDVEGI (HU) 1993-07-14 CN claimed