Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12113905 | 0.86 | TSHR (0.46) | FFAR1TSHRLOXL2 | |
| SCHEMBL2153847 | 0.82 | HRH3 (0.59) | IDH1HRH3GLAFFAR1TSHR | |
| SCHEMBL23958863 | 0.79 | FFAR1 (0.46) | IDH1FFAR1TSHRFFAR4LOXL2 | |
| SCHEMBL4196662 | 0.77 | HRH3 (0.54) | IDH1HRH3GLAFFAR1TSHR | |
| SCHEMBL7626603 | 0.75 | CLK4 (0.47) | TSHR | |
| SCHEMBL26987873 | 0.75 | HRH3 (0.49) | IDH1HRH3GLAFFAR1CYP19A1 | |
| SCHEMBL481239 | 0.75 | HRH3 (0.49) | IDH1HRH3GLAFFAR1CYP19A1 | |
| SCHEMBL1003188 | 0.74 | TSHR (0.50) | FFAR1TSHRCYP11B1CYP11B2FFAR4 | |
| SCHEMBL18609498 | 0.74 | IDH1 (0.47) | IDH1HRH3GLASCN8ACYP19A1 | |
| SCHEMBL18641315 | 0.74 | LTA4H (0.58) | IDH1HRH3GLAFFAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113263-A1 | CRF RECEPTOR ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-06-10 | — | — | WO | disclosed |