Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.73 |
| ▸ | THRA | P10827 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 3/20 | 0.61 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30503435 | 1.00 | EGLN1 (0.73) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL23493325 | 0.94 | EGLN1 (0.83) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL30503451 | 0.94 | EGLN1 (0.83) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL30503431 | 0.92 | EGLN1 (0.78) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL23493329 | 0.92 | EGLN1 (0.78) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL23493323 | 0.92 | EGLN1 (0.80) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL30503453 | 0.92 | EGLN1 (0.80) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL23493355 | 0.92 | EGLN1 (0.81) | EGLN1THRATHRB | |
| SCHEMBL30503434 | 0.92 | EGLN1 (0.81) | EGLN1THRATHRB | |
| SCHEMBL23493352 | 0.85 | EGLN1 (0.84) | EGLN1THRATHRBBBOX1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981669-B2 | 1,7-naphthyridine derivative and preparation method and use therefor | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) | 2024-05-14 | — | — | US | disclosed |
| CN-112689635-B | 1, 7-naphthyridine derivative and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2023-08-04 | — | — | CN | disclosed |
| US-20210332043-A1 | 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) | 2021-10-28 | — | — | US | disclosed |
| US-20210332043-A1 | 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) | 2021-10-28 | — | — | US | disclosed |
| EP-3835300-A1 | 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2021-06-16 | — | — | EP | disclosed |
| EP-3835300-A1 | 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2021-06-16 | — | — | EP | disclosed |
| CN-112689635-A | 1, 7-naphthyridine derivative and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-110878096-A | 1, 7-naphthyridine derivative and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2020-03-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332043-A1 | 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR | HIF1A, HIF1AN, P4HA1 | EGLN1 6/4885THRA 2766/4885THRB 2516/4885 |
| US-11981669-B2 | 1,7-naphthyridine derivative and preparation method and use therefor | HIF1A, HIF1AN, P4HA1 | EGLN1 6/4885THRA 2766/4885THRB 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.