Sugi Predict

Sugi Predict / Targets / P4HA1

P4HA1

Prolyl 4-hydroxylase subunit alpha-1 · P13674 · P4HA1 on Sugi Atlas →

4,170 patent compounds predicted against P4HA1, 2,649 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL68560 SCHEMBL68560 1.00 3/20
SCHEMBL687378 SCHEMBL687378 0.74 3/20
SCHEMBL505455 SCHEMBL505455 0.73 3/20
SCHEMBL503140 SCHEMBL503140 0.68 3/20
SCHEMBL2556293 SCHEMBL2556293 0.66 3/20
SCHEMBL2947695 SCHEMBL2947695 0.66 3/20
SCHEMBL185991 SCHEMBL185991 0.64 3/20
SCHEMBL3196986 SCHEMBL3196986 0.64 3/20
SCHEMBL1542758 SCHEMBL1542758 0.63 3/20
SCHEMBL2070382 SCHEMBL2070382 0.63 3/20
SCHEMBL3203648 SCHEMBL3203648 0.63 3/20
SCHEMBL3868273 SCHEMBL3868273 0.63 3/20
SCHEMBL38414 SCHEMBL38414 0.61 3/20
SCHEMBL42011 SCHEMBL42011 0.61 3/20
SCHEMBL471650 SCHEMBL471650 0.61 3/20
SCHEMBL565986 SCHEMBL565986 0.61 3/20
SCHEMBL646556 SCHEMBL646556 0.61 3/20
6-Mercaptonicotinic Acid 6-Mercaptonicotinic Acid (SCHEMBL796849) 0.61 3/20
SCHEMBL1505306 SCHEMBL1505306 0.61 3/20
SCHEMBL2027693 SCHEMBL2027693 0.61 3/20

Clinical trials — most relevant to P4HA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients PHASE4NOT_YET_RECRUITING
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy PHASE2NOT_YET_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Carnosine for Peripheral Vascular Disease PHASE2UNKNOWN
Study of the Effects of Iron on Lung Blood Pressure at High Altitude PHASE2WITHDRAWN
A Study of Efficacy and Safety of AND017 in Patients With Myelodysplastic Syndrome PHASE2RECRUITING
A Study of AND017 to Treat Cancer Related Anemia in Patients Not Receiving Chemotherapy PHASE2NOT_YET_RECRUITING
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease PHASE1/PHASE2COMPLETED
MBM-02 (Tempol) for the Treatment of Glioblastoma Multiforme (GBM) PHASE2UNKNOWN
Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing PHASE1WITHDRAWN
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery nanCOMPLETED
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
Study of the Effects of Iron Levels on the Lungs at High Altitude nanCOMPLETED
Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock nanCOMPLETED
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Prevention of Secondary Hyperparathyroidism With Vitamin D in Stage II/III Chronic Kidney Disease nanCOMPLETED
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity nanCOMPLETED
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN
Drivers of Hypoxia-induced Angiogenesis in Tumor Development nanUNKNOWN
Genes-in-Action - Hepcidin Regulation of Iron Supplementation nanCOMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS) nanCOMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
Hypoxia Inducible factor1-Alpha Genetic Polymorphism of Obstructive Sleep Apnea nanUNKNOWN
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions nanRECRUITING
Selecting Hypoxic Tumours for Treatment Modification nanRECRUITING
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC) nanRECRUITING
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact nanCOMPLETED
Predictors of Outcome of Pediatric Renal Transplantation nanNOT_YET_RECRUITING
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a P4HA1 binder may also engage these)

ProteinNameSimilarity
Q5RAG8 — 1.000 Q5RAG8 →
Q1RMU3 — 1.000 Q1RMU3 →
Q60715 — 1.000 Q60715 →
P54001 — 1.000 P54001 →
P16924 — 1.000 P16924 →
Q10576 — 1.000 Q10576 →
Q5ZLK5 — 1.000 Q5ZLK5 →
Q60716 — 0.997 Q60716 →
O15460 — 0.996 O15460 →
Q20065 — 0.995 Q20065 →
Q7Z4N8 — 0.985 Q7Z4N8 →
Q6W3F0 — 0.984 Q6W3F0 →
Q8CF93 — 0.983 Q8CF93 →
Q17FB8 — 0.982 Q17FB8 →
GALNT13 Polypeptide N-acetylgalactosaminyltransferase 13 0.982 landscape →
Q29121 — 0.981 Q29121 →
Q6W3E9 — 0.981 Q6W3E9 →
Q6UE39 — 0.981 Q6UE39 →
GALNT1 Polypeptide N-acetylgalactosaminyltransferase 1 0.980 landscape →
Q9H3G5 — 0.980 Q9H3G5 →
G5EFE7 — 0.979 G5EFE7 →
O77633 — 0.979 O77633 →
Q9VYV5 — 0.978 Q9VYV5 →
Q811A3 — 0.978 Q811A3 →
Q8IPK4 — 0.978 Q8IPK4 →
O08912 — 0.978 O08912 →
Q07537 — 0.978 Q07537 →
S5S833 — 0.978 S5S833 →
Q10741 — 0.978 Q10741 →
Q49A17 — 0.978 Q49A17 →