Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL6308369 | 0.95 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2ALDH1A1TSHR | |
| Ether SCHEMBL1001966 | 0.92 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2ALDH1A1TSHR | |
| Ether SCHEMBL27602732 | 0.86 | ALDH1A1 (0.48) | GLRA1SLC6A9OR51E2ALDH1A1TSHR | |
| Ether SCHEMBL28328411 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LMNAHSD17B10 | |
| Ether SCHEMBL115545 | 0.86 | — | — | |
| Ether SCHEMBL20338904 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LMNAHSD17B10 | |
| Ether SCHEMBL28393262 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LMNAHSD17B10 | |
| Ether SCHEMBL7115101 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LMNAHSD17B10 | |
| Ether SCHEMBL5072098 | 0.83 | GLRA1 (0.46) | GLRA1SLC6A9OR51E2ALDH1A1TSHR | |
| 1,4-Butanediol SCHEMBL7192834 | 0.83 | GLRA1 (0.46) | GLRA1SLC6A9OR51E2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021115750-A1 | INK BASED ON SILVER NANOPARTICLES | GENES'INK (FR) | 2021-06-17 | — | — | WO | disclosed |