Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 7/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23501220 | 0.87 | CLK1 (0.46) | MARK3RETMET | |
| SCHEMBL25812361 | 0.86 | RET (0.42) | MARK3RETHSP90AA1HSP90AB1 | |
| SCHEMBL23501179 | 0.84 | RET (0.44) | RETLOXL2 | |
| SCHEMBL23501280 | 0.82 | RET (0.43) | RET | |
| SCHEMBL23501131 | 0.82 | MKNK1 (0.46) | RETJAK1JAK3JAK2TYK2 | |
| SCHEMBL23501312 | 0.81 | ALDH1A1 (0.40) | RETPIK3CDKDR | |
| SCHEMBL23501223 | 0.80 | TTK (0.42) | RET | |
| SCHEMBL23501196 | 0.79 | MAPK14 (0.38) | MARK3MAPK14 | |
| SCHEMBL25426039 | 0.79 | MARK3 (0.42) | MARK3RETHSP90AA1HSP90AB1LOXL2 | |
| SCHEMBL23501127 | 0.75 | PIK3CG (0.51) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939967-B | Pyrazolo [1,5-a ] pyridine compound, and preparation method and application thereof | 深圳众格生物科技有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-114787161-B | Pyrazolo [1,5-a ] pyridine compound, and preparation method and application thereof | 深圳众格生物科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| US-20230219979-A1 | PYRAZOLO[1,5-a]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
| EP-4074710-A1 | PYRAZOLO[1,5-A]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shenzhen Zhongge Biological Technology Co., Ltd (CN) | 2022-10-19 | — | — | EP | disclosed |
| WO-2021115457-A9 | PYRAZOLO[1,5-A]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳众格生物科技有限公司 | 2022-05-19 | — | — | WO | disclosed |
| WO-2021115457-A1 | PYRAZOLO[1,5-A]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳晶泰科技有限公司 | 2021-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219979-A1 | PYRAZOLO[1,5-a]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | RET, GRK4, RIN1 | MARK3 2052/4885RET 1/4885HSP90AA1 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.