SCHEMBL23503085

SCHEMBL23503085

N#Cc1cccc(C#N)c1-c1cccc(-n2c3ccccc3c3ccc4c5ccccc5n(-c5cc(-c6ccccc6)cc(-c6ccccc6)c5)c4c32)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.36
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 5/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
HPGD P15428 2/20 0.35
MAPK1 P28482 2/20 0.35
LMNA P02545 1/20 0.35
TDP1 Q9NUW8 4/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
MAOA P21397 2/20 0.33
TSHR P16473 2/20 0.33
FASN P49327 1/20 0.32
HIF1A Q16665 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23503207 0.95 KDM4E (0.38) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503201 0.94 KDM4E (0.42) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503084 0.93 KDM4E (0.40) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503010 0.92 KDM4E (0.35) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503284 0.92 KDM4E (0.35) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL20413221 0.90 IMPDH2 (0.36) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503260 0.89 ATM (0.41) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23502956 0.88 ATM (0.40) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL22737630 0.88 KDM4E (0.38) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL23503176 0.87 ATM (0.37) KDM4EATML3MBTL1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038117-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2021-06-15 US disclosed