Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30265334 | 1.00 | POLB (0.60) | POLBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL30265188 | 0.91 | POLB (0.60) | POLBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL13373331 | 0.89 | PARP1 (0.57) | CYP1A2CYP2D6ALDH1A1PARP1HPGD | |
| SCHEMBL16240465 | 0.86 | KMT2A (0.47) | POLBALDH1A1MAPK1HTR1APARP1 | |
| SCHEMBL30265074 | 0.85 | TSHR (0.58) | POLBCYP2D6ALDH1A1KDM4E | |
| SCHEMBL14385060 | 0.83 | ALDH1A1 (0.56) | ALDH1A1 | |
| SCHEMBL4811540 | 0.82 | POLB (0.60) | POLBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL14430690 | 0.82 | KMT2A (0.60) | POLBALDH1A1PARP1KDM4E | |
| SCHEMBL3736562 | 0.80 | SMN1; SMN2 (0.51) | ALDH1A1MAPK1CD274KDM4E | |
| SCHEMBL30265367 | 0.80 | HTT (0.61) | POLBCYP1A2CYP2D6ALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| WO-2011103018-A1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-08-25 | — | — | WO | disclosed |