Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.59 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345469 | 0.95 | MAPK14 (0.57) | MAPK14ABL1RIPK2ROCK1 | |
| SCHEMBL2347532 | 0.80 | MAPK14 (0.71) | MAPK14ABL1HSPB1KCNK3KCNK9 | |
| SCHEMBL2347961 | 0.78 | MAPK14 (0.62) | MAPK14ABL1RAF1HSPB1LYN | |
| SCHEMBL2346102 | 0.78 | MAPK14 (0.65) | MAPK14ABL1RAF1HSPB1LYN | |
| SCHEMBL2346050 | 0.77 | ABL1 (0.67) | MAPK14ABL1HSPB1KCNK3KCNK9 | |
| SCHEMBL2911825 | 0.77 | MAPK14 (0.71) | MAPK14ABL1KDM4E | |
| SCHEMBL2342855 | 0.77 | MAPK14 (0.71) | MAPK14ABL1KDM4E | |
| SCHEMBL2912814 | 0.75 | MAPK14 (0.71) | MAPK14ABL1KDM4EHTT | |
| SCHEMBL2346300 | 0.75 | MAPK14 (0.61) | MAPK14ABL1 | |
| SCHEMBL2352219 | 0.75 | ABL1 (0.64) | MAPK14ABL1RAF1HSPB1LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |