Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346102 | 0.93 | MAPK14 (0.65) | MAPK14ABL1LMNA | |
| SCHEMBL2352219 | 0.90 | ABL1 (0.64) | MAPK14ABL1LMNA | |
| SCHEMBL2347964 | 0.89 | ABL1 (0.65) | MAPK14ABL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL2347532 | 0.85 | MAPK14 (0.71) | MAPK14ABL1 | |
| SCHEMBL14344806 | 0.85 | ABL1 (0.62) | MAPK14ABL1 | |
| SCHEMBL12459047 | 0.84 | ALDH1A1 (0.65) | MAPK14ABL1RAB9ANPC1MAPT | |
| SCHEMBL2914470 | 0.84 | HIF1A (0.64) | RAB9ANPC1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL3919974 | 0.83 | ABL1 (0.63) | MAPK14ABL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL2346050 | 0.82 | ABL1 (0.67) | MAPK14ABL1 | |
| SCHEMBL2346273 | 0.82 | RAB9A (0.61) | MAPK14RAB9ANPC1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |