Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CASP1 | P29466 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | TP53 | P04637 | 9/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754541 | 0.79 | MAPT (0.54) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2321122 | 0.79 | HTR1B (0.59) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL8869642 | 0.79 | HTR1B (0.47) | — | |
| Hydrochloric Acid SCHEMBL7026693 | 0.78 | HTR1B (0.58) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8646717 | 0.78 | HTR1B (0.48) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6924873 | 0.77 | MAPT (0.56) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL980209 | 0.77 | HTR1B (0.61) | MEN1KMT2A | |
| SCHEMBL7031093 | 0.77 | HTR1B (0.61) | MEN1KMT2A | |
| SCHEMBL2301469 | 0.77 | HTR1B (0.61) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3466984 | 0.76 | HTR1B (0.60) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327016-B1 | PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2021-06-16 | — | — | EP | disclosed |