Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | HTR1D | P28221 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | RB1 | P06400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031093 | 1.00 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL2301469 | 1.00 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Bromide SCHEMBL7027435 | 0.99 | HTR1B (0.60) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL3466984 | 0.99 | HTR1B (0.60) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL7026151 | 0.94 | HTR1B (0.59) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Oxalic Acid SCHEMBL7540895 | 0.94 | HTR1B (0.62) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7700352 | 0.92 | HTR1B (0.68) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7024837 | 0.92 | HTR1B (0.68) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL16318529 | 0.91 | HTR1B (0.69) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Succinic Acid SCHEMBL7025602 | 0.91 | HTR1B (0.69) | HTR1BHTR1AHTR1DDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674621-B1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | VERNALIS LTD (GB) | 2003-02-26 | — | — | EP | claimed |
| US-20020032192-A1 | Treatment of vasodilatory headache | VERNALIS LIMITED (GB) | 2002-03-14 | — | — | US | claimed |
| WO-1999022730-A1 | USE OF (+)-6-CARBOXAMIDO-3-METHYLAMINO-1,2,3,4-TETRAHYDROCARBAZOLE FOR TREATING HYPERALGESIA | VANGUARD MEDICA LIMITED (GB) | 1999-05-14 | — | — | WO | claimed |
| EP-0603432-B1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0591280-B1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5618947-A | SEPARATING THE RACEMIC MIXTURE BY CHROMATOGRAPHY | SMITHKLINE BEECHAM, P.L.C. (GB) | 1997-04-08 | — | — | US | claimed |
| US-5618948-A | TREATMENT OF 6-CARBOXAMIDO-3-METHYLAMINO-1,2,3,4-TETRAHYDROCARBAZOLE WITH 2-PYRROLIDONE-5-CARBOXYLIC ACID, CRYSTALLIZATION | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-04-08 | — | — | US | claimed |
| US-5616603-A | TREATING MIGRAINES | SMITHKLINE BEECHAM PLC (GB) | 1997-04-01 | — | — | US | claimed |
| US-5464864-A | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-07 | — | — | US | claimed |
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | claimed |
| EP-2816030-A1 | Process for the preparation of frovatriptan and its enantiomer | Duke Chem, S. A. (ES) | 2014-12-24 | — | — | EP | disclosed |
| WO-2014202717-A1 | PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND ITS ENANTIOMER | DUKE CHEM, S.A. (ES) | 2014-12-24 | — | — | WO | disclosed |
| US-20110002967-A1 | Methods of Transdermally Administering an Indole Serotonin Receptor Agonist and Transdermal Compositions for Use in the Same | TEIKOKU PHARMA USA, INC. | 2011-01-06 | — | — | US | disclosed |
| WO-2010122343-A1 | A PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND FROVATRIPTAN SUCCINATE AND THEIR SYNTHETIC INTERMEDIATES | GENERICS [UK] LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |
| US-5464864-A | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-07 | — | — | US | disclosed |
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032192-A1 | Treatment of vasodilatory headache | CNR1, CNR2, EDNRA | HTR1B 71/4885HTR1A 36/4885HTR1D 26/4885 |
| US-20110002967-A1 | Methods of Transdermally Administering an Indole Serotonin Receptor Agonist and Transdermal Compositions for Use in the Same | HTR7, TPH1, TPH2 | HTR1B 14/4885HTR1A 5/4885HTR1D 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.