SCHEMBL23509532

SCHEMBL23509532

NN1CCC(c2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)CC1

nearest known ligand 0.68

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ IKZF2 Q9UKS7 7/20 0.68
▸ IKZF1 Q13422 1/20 0.68
▸ CRBN Q96SW2 13/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25010615 0.91 IKZF2 (0.69) IKZF2IKZF1CRBN
SCHEMBL23105167 0.91 IKZF2 (0.69) IKZF2IKZF1CRBN
SCHEMBL23092298 0.87 IKZF2 (0.65) IKZF2IKZF1CRBN
SCHEMBL31065139 0.87 IKZF2 (0.65) IKZF2IKZF1CRBN
SCHEMBL25079613 0.87 IKZF2 (0.65) IKZF2IKZF1CRBN
SCHEMBL23092333 0.87 IKZF2 (0.65) IKZF2IKZF1CRBN
SCHEMBL24850604 0.87 IKZF2 (0.73) IKZF2IKZF1CRBN
Hydrochloric Acid SCHEMBL25415969 0.86 IKZF2 (0.64) IKZF2IKZF1CRBN
Hydrochloric Acid SCHEMBL29663710 0.86 IKZF2 (0.64) IKZF2IKZF1CRBN
SCHEMBL26610764 0.86 IKZF2 (0.64) IKZF2IKZF1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021119571-A1 PDE4 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BIOTHERYX, INC. (US) 2021-06-17 — — WO disclosed
Send feedback