Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705576 | 0.95 | IRAK4 (0.52) | IRAK4ALDH1A1SMN1; SMN2MAPTPRKCZ | |
| SCHEMBL17961796 | 0.89 | IRAK4 (0.50) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| SCHEMBL30632323 | 0.89 | IRAK4 (0.50) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| SCHEMBL6216854 | 0.89 | IRAK4 (0.50) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| SCHEMBL13326544 | 0.89 | IRAK4 (0.50) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| SCHEMBL25422820 | 0.89 | IRAK4 (0.50) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| Hydrochloric Acid SCHEMBL4056189 | 0.88 | IRAK4 (0.49) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| Hydrochloric Acid SCHEMBL4056190 | 0.88 | IRAK4 (0.49) | IRAK4PRKD1PRKD2FLT3IRAK1 | |
| SCHEMBL16548498 | 0.84 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18497478 | 0.82 | HRH3 (0.53) | IRAK4ALDH1A1SMN1; SMN2FLT3MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531503-A1 | GAMMA SECRETASE MODULATERS | F. Hoffmann-La Roche AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011092272-A1 | GAMMA SECRETASE MODULATERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-04 | — | — | WO | disclosed |