Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29653671 | 1.00 | TLR8 (0.34) | TLR8TLR7DHFRDCPSAPP | |
| SCHEMBL23500838 | 0.85 | CXCR2 (0.39) | TLR8TLR7APP | |
| SCHEMBL23500840 | 0.85 | CXCR2 (0.39) | TLR8TLR7APP | |
| SCHEMBL23514158 | 0.80 | TLR7 (0.45) | TLR8TLR7APPCYP2D6 | |
| SCHEMBL29653636 | 0.80 | TLR7 (0.45) | TLR8TLR7APPCYP2D6 | |
| SCHEMBL30827111 | 0.79 | KCNH2 (0.37) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL23513853 | 0.79 | KCNH2 (0.37) | TLR8TLR7CYP2D6DRD1HTR2A | |
| SCHEMBL29653633 | 0.78 | PRKCI (0.34) | APP | |
| SCHEMBL23513935 | 0.78 | PRKCI (0.34) | APP | |
| SCHEMBL23500832 | 0.75 | TLR8 (0.43) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021114691-A1 | NITROGEN-CONTAINING RING-FUSED COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-06-17 | — | — | WO | disclosed |