Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23455434 | 0.84 | ITGB1 (0.46) | MAPTGPR139ROCK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL23455435 | 0.84 | ITGB1 (0.46) | MAPTGPR139ROCK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL23489403 | 0.81 | ITGB1 (0.41) | MAPTGPR139ROCK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL30000520 | 0.81 | ITGB1 (0.54) | MAPTGPR139ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23455498 | 0.81 | ITGB1 (0.54) | MAPTGPR139ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23455496 | 0.81 | ITGB1 (0.54) | MAPTGPR139ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23489292 | 0.80 | ABL1 (0.49) | MAPTROCK1L3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL23455528 | 0.80 | MAPT (0.67) | MAPTROCK1SMN1; SMN2TP53RAB9A | |
| SCHEMBL23518428 | 0.79 | ITGB1 (0.39) | MAPTGPR139ROCK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL23518452 | 0.77 | ALDH1A1 (0.44) | GPR139SMN1; SMN2TP53RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021119199-A1 | ALPHA-5 BETA-1 INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-06-17 | — | — | WO | disclosed |