Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 10/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652 | 0.91 | — | — | |
| Water SCHEMBL6908198 | 0.91 | LPAR3 (0.41) | LPAR3LPAR2LPAR1 | |
| SCHEMBL6653137 | 0.89 | LPAR3 (0.40) | LPAR3LPAR2LPAR1 | |
| SCHEMBL7216239 | 0.89 | LPAR3 (0.40) | LPAR3LPAR2LPAR1 | |
| SCHEMBL28830258 | 0.89 | LPAR3 (0.40) | LPAR3LPAR2LPAR1 | |
| Water SCHEMBL11512537 | 0.89 | LPAR3 (0.40) | LPAR3LPAR2LPAR1 | |
| SCHEMBL6998234 | 0.89 | LPAR3 (0.40) | LPAR3LPAR2LPAR1 | |
| SCHEMBL8445541 | 0.82 | LPAR3 (0.35) | LPAR3LPAR2LPAR1 | |
| SCHEMBL7912997 | 0.80 | LPAR3 (0.39) | LPAR3LPAR2LPAR1TSHR | |
| SCHEMBL29285241 | 0.79 | TSHR (0.34) | LPAR3LPAR2LPAR1PPARDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560982-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | Chemgenes Corporation (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011103468-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | CHEMGENES CORPORATION (US) | 2011-08-25 | — | — | WO | claimed |
| EP-2560982-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | Chemgenes Corporation (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011103468-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | CHEMGENES CORPORATION (US) | 2011-08-25 | — | — | WO | disclosed |