Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 8/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.41 |
| ▸ | TPI1 | P60174 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652 | 1.00 | — | — | |
| SCHEMBL7216239 | 0.98 | LPAR3 (0.40) | LPAR3LPAR2LPAR1TPI1ALDH1A1 | |
| SCHEMBL6653137 | 0.98 | LPAR3 (0.40) | LPAR3LPAR2LPAR1TPI1ALDH1A1 | |
| Water SCHEMBL11512537 | 0.98 | LPAR3 (0.40) | LPAR3LPAR2LPAR1TPI1ALDH1A1 | |
| SCHEMBL6998234 | 0.98 | LPAR3 (0.40) | LPAR3LPAR2LPAR1TPI1ALDH1A1 | |
| SCHEMBL28830258 | 0.98 | LPAR3 (0.40) | LPAR3LPAR2LPAR1TPI1ALDH1A1 | |
| Alcohol SCHEMBL2352329 | 0.91 | LPAR3 (0.45) | LPAR3LPAR2LPAR1 | |
| SCHEMBL8445541 | 0.89 | LPAR3 (0.35) | LPAR3LPAR2LPAR1 | |
| SCHEMBL7912997 | 0.88 | LPAR3 (0.39) | LPAR3LPAR2LPAR1ALDH1A1 | |
| SCHEMBL497349 | 0.85 | P2RY14 (0.34) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737085-B2 | NATURALLY DERIVED ANTIDEPRESSANT COMPOSITION IN THE FORM OF A FOOD, DIETARY SUPPLEMENT, MEDICINE OR THE LIKE THAT CONTAINS NEITHER HYPERICIN NOR HYPERFORIN AND IS SAFER EVEN DURING EXTENDED ADMINISTRATION, FOR THERAPY OF DEPRESSION | TOKIWA PHYTOCHEMICAL CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| US-20020090403-A1 | Antidepressant | TOKIWA PHYTOCHEMICAL CO., LTD. (JP) | 2002-07-11 | — | — | US | disclosed |
| US-6113907-A | MEASUREMENT OF SAMPLE, BINDING AND DETERMINATION OF HYPERICIN CONCENTRATION FOR MUSCARINIC M1 RECEPTORS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-09-05 | — | — | US | disclosed |