Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 18/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28657089 | 0.99 | MAP3K5 (0.51) | MAP3K5KDM4EKDM6BTET3KDM4A | |
| SCHEMBL21461157 | 0.89 | MAP3K5 (0.52) | MAP3K5 | |
| SCHEMBL28668610 | 0.88 | MAP3K5 (0.53) | MAP3K5 | |
| SCHEMBL21461103 | 0.85 | MAP3K5 (0.52) | MAP3K5 | |
| SCHEMBL27959304 | 0.78 | MAP3K5 (0.52) | MAP3K5KDM4EALDH1A1MAPTKMO | |
| SCHEMBL1698793 | 0.78 | MAP3K5 (0.53) | MAP3K5 | |
| SCHEMBL28653518 | 0.77 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL21461042 | 0.77 | MAP3K5 (0.42) | MAP3K5 | |
| SCHEMBL28848714 | 0.77 | MAP3K5 (0.42) | MAP3K5 | |
| SCHEMBL28848732 | 0.77 | MAP3K5 (0.42) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4537902-A2 | TRICYCLIC ASK1 INHIBITORS | Terns, Inc. (US) | 2025-04-16 | — | — | EP | disclosed |
| EP-3773577-B1 | TRICYCLIC ASK1 INHIBITORS | TERNS INC (US) | 2024-11-20 | — | — | EP | disclosed |
| CN-109400625-B | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2021-11-12 | — | — | CN | disclosed |
| EP-3773577-A1 | TRICYCLIC ASK1 INHIBITORS | Terns, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10919911-B2 | Tricyclic ASK1 inhibitors | Terns, Inc. (US) | 2021-02-16 | — | — | US | disclosed |
| US-10919911-B2 | Tricyclic ASK1 inhibitors | Terns, Inc. (US) | 2021-02-16 | — | — | US | disclosed |
| US-RE48150-E1 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-RE48150-E1 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| WO-2019200267-A1 | TRICYCLIC ASK1 INHIBITORS | Terns, Inc. (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2019200267-A1 | TRICYCLIC ASK1 INHIBITORS | Terns, Inc. (US) | 2019-10-17 | — | — | WO | disclosed |
| US-8440665-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440665-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440665-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2588475-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| CN-102985418-A | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES INC | 2013-03-20 | — | — | CN | disclosed |
| US-20120004267-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004267-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004267-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| WO-2012003387-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012003387-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919911-B2 | Tricyclic ASK1 inhibitors | MAP3K1, MAP3K8, MAP3K20 | MAP3K5 12/4885KDM4E 2558/4885KDM6B 2019/4885 |
| US-20120004267-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | AIFM1, MAP3K1, RIPK3 | MAP3K5 11/4885KDM4E 2886/4885KDM6B 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.