Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352195 | 0.93 | HTT (0.56) | HTTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL30265382 | 0.90 | HTT (0.67) | HTTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL13373316 | 0.86 | HTT (0.57) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL31047555 | 0.84 | EPHX1 (0.58) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL31047594 | 0.84 | EPHX1 (0.58) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL2352590 | 0.84 | HTT (0.54) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL30265252 | 0.82 | HTT (0.70) | HTTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL6783835 | 0.82 | HTT (0.53) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL2356085 | 0.82 | HTT (0.53) | HTTPOLBL3MBTL1TDP1HDAC6 | |
| SCHEMBL396107 | 0.82 | POLB (0.53) | HTTPOLBL3MBTL1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103018-A1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-08-25 | — | — | WO | disclosed |