Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8741042 | 0.87 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ALMNADPP4 | |
| SCHEMBL1683063 | 0.80 | ALDH1A1 (0.45) | TDP1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9178860 | 0.80 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ALMNADPP4 | |
| SCHEMBL654305 | 0.78 | ALDH1A1 (0.42) | TDP1ALDH1A1KMT2A | |
| SCHEMBL28320454 | 0.78 | ALDH1A1 (0.40) | TDP1ALDH1A1CYP3A4LMNA | |
| SCHEMBL17688553 | 0.78 | ALDH1A1 (0.39) | TDP1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL7252003 | 0.75 | ALDH1A1 (0.41) | TDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL9874189 | 0.75 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2ALMNADPP4 | |
| SCHEMBL10537484 | 0.75 | TSHR (0.37) | TDP1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL23532412 | 0.74 | ALDH1A1 (0.39) | TDP1ALDH1A1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021123785-A1 | DNA POLYMERASE THETA INHIBITORS | ARTIOS PHARMA LIMITED (GB) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021123785-A1 | DNA POLYMERASE THETA INHIBITORS | ARTIOS PHARMA LIMITED (GB) | 2021-06-24 | — | — | WO | disclosed |