Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30025652 | 1.00 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6SRCALDH1A1 | |
| SCHEMBL23534517 | 1.00 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6SRCALDH1A1 | |
| SCHEMBL30024029 | 0.83 | KDM4E (0.37) | SRCALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL23535042 | 0.83 | KDM4E (0.37) | SRCALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL23534268 | 0.82 | PARP10 (0.39) | CYP3A4ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL30058516 | 0.79 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6SRCALDH1A1 | |
| SCHEMBL23534056 | 0.79 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6SRCALDH1A1 | |
| SCHEMBL23535342 | 0.78 | CCNE2 (0.44) | CYP3A4CYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL8068792 | 0.72 | NR4A2 (0.49) | CYP1A2ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL15110876 | 0.67 | DHODH (0.41) | CYP3A4MAPTKMT2APOLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076459-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |