Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638044 | 0.80 | CCR1 (0.87) | CCR1 | |
| SCHEMBL2357443 | 0.79 | CCR1 (0.41) | CCR1 | |
| SCHEMBL3635896 | 0.79 | CCR1 (0.48) | CCR1ALKMAPTMETAP1 | |
| SCHEMBL3635666 | 0.78 | CCR1 (0.50) | CCR1ALKMAPT | |
| SCHEMBL3637059 | 0.77 | CCR1 (0.49) | CCR1ALKMAPT | |
| SCHEMBL3632308 | 0.77 | CCR1 (0.46) | CCR1ALKMAPTBRD4 | |
| SCHEMBL3634930 | 0.77 | CCR1 (0.46) | CCR1ALKMAPTPTGDR | |
| SCHEMBL4696966 | 0.77 | CCR1 (0.51) | CCR1ALKMAPT | |
| SCHEMBL2354678 | 0.76 | CCR1 (0.48) | CCR1ALKMAPT | |
| SCHEMBL3640142 | 0.76 | CCR1 (0.48) | CCR1LMNAALKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352501-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010051561-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | CHEMOCENTRYX, INC. (US) | 2010-05-06 | — | — | WO | disclosed |