Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1637373 | 0.81 | CCR1 (0.64) | CCR1 | |
| SCHEMBL2353590 | 0.79 | CCR1 (0.57) | CCR1 | |
| SCHEMBL28812577 | 0.79 | CCR1 (0.54) | CCR1HTR1AHTR2A | |
| SCHEMBL2351890 | 0.77 | HTT (0.40) | — | |
| SCHEMBL3639958 | 0.76 | ALDH1A1 (0.35) | CCR1 | |
| SCHEMBL28812576 | 0.75 | CCR1 (0.58) | CCR1 | |
| SCHEMBL16500356 | 0.74 | SRC (0.40) | CCR1 | |
| SCHEMBL2353633 | 0.73 | CCR1 (0.61) | CCR1 | |
| SCHEMBL1638723 | 0.73 | CCR1 (0.67) | CCR1 | |
| SCHEMBL12626194 | 0.72 | CCR1 (0.58) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352501-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010051561-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | CHEMOCENTRYX, INC. (US) | 2010-05-06 | — | — | WO | disclosed |