Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931966 | 1.00 | TSHR (0.43) | TSHRNPSR1GRM2LMNAHTT | |
| SCHEMBL23536124 | 0.90 | TSHR (0.39) | TSHRNPSR1GRM2LMNAHTT | |
| SCHEMBL29931867 | 0.90 | TSHR (0.39) | TSHRNPSR1GRM2LMNAHTT | |
| SCHEMBL21244041 | 0.86 | TSHR (0.50) | TSHRNPSR1GRM2LMNAHTT | |
| SCHEMBL29931916 | 0.84 | KMT2A (0.39) | TSHRNPSR1LMNAHTTALDH1A1 | |
| SCHEMBL23536112 | 0.83 | POLB (0.42) | TSHRGRM2LMNAHTTALDH1A1 | |
| SCHEMBL29948574 | 0.83 | POLB (0.42) | TSHRGRM2LMNAHTTALDH1A1 | |
| SCHEMBL29931848 | 0.83 | GRM2 (0.39) | TSHRNPSR1GRM2ALDH1A1MAPT | |
| SCHEMBL23536038 | 0.81 | OPRL1 (0.37) | TSHRNPSR1GRM2MEN1KMT2A | |
| SCHEMBL28867507 | 0.81 | OPRL1 (0.37) | TSHRNPSR1GRM2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |