Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536112 | 1.00 | POLB (0.42) | POLBTHRBHTR6LMNAKMT2A | |
| SCHEMBL29931921 | 0.89 | POLB (0.41) | POLBTHRBHTR6LMNAKMT2A | |
| SCHEMBL23536117 | 0.89 | POLB (0.41) | POLBTHRBHTR6LMNAKMT2A | |
| SCHEMBL28867404 | 0.88 | LMNA (0.39) | POLBLMNAMAPTTSHRMAPK1 | |
| SCHEMBL29931982 | 0.85 | PGR (0.43) | POLBHTR6LMNAKMT2AMEN1 | |
| SCHEMBL23536108 | 0.85 | PGR (0.43) | POLBHTR6LMNAKMT2AMEN1 | |
| SCHEMBL29932141 | 0.84 | SMN1; SMN2 (0.41) | POLBTHRBLMNAKMT2AMEN1 | |
| SCHEMBL23536165 | 0.83 | TSHR (0.43) | POLBLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL29931966 | 0.83 | TSHR (0.43) | POLBLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL29931915 | 0.83 | ALDH1A1 (0.39) | LMNAKMT2AALDH1A1HTTGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |