Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | LGMN | Q99538 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29948520 | 1.00 | KDM4E (0.54) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL14804205 | 0.89 | KDM4E (0.64) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL29948481 | 0.86 | SMN1; SMN2 (0.49) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL23536337 | 0.86 | SMN1; SMN2 (0.49) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL14804206 | 0.83 | TSHR (0.67) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL23536095 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL23536170 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL29948600 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL29948562 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2TSHRPOLBKMT2A | |
| SCHEMBL23536097 | 0.81 | MAPT (0.58) | KDM4ESMN1; SMN2TSHRPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |