Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536337 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL29948520 | 0.86 | KDM4E (0.54) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL23536343 | 0.86 | KDM4E (0.54) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL14804205 | 0.84 | KDM4E (0.64) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL23536016 | 0.80 | KMT2A (0.47) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL14804206 | 0.79 | TSHR (0.67) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL23536170 | 0.78 | KDM4E (0.57) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL29948562 | 0.78 | KDM4E (0.57) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL23536095 | 0.78 | KDM4E (0.57) | SMN1; SMN2KDM4EPOLBTSHRKMT2A | |
| SCHEMBL29948600 | 0.78 | KDM4E (0.57) | SMN1; SMN2KDM4EPOLBTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |