SCHEMBL23536352

SCHEMBL23536352

CCOCC1(C)CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HPGD P15428 1/20 0.40
EPHX2 P34913 1/20 0.40
TACR1 P25103 1/20 0.39
RECQL P46063 1/20 0.38
EPHX1 P07099 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
NR1H2 P55055 1/20 0.38
DDB1 Q16531 1/20 0.38
CRBN Q96SW2 1/20 0.38
ADORA1 P30542 1/20 0.38
SCD5 Q86SK9 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28983610 0.86 SMN1; SMN2 (0.40) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL27127518 0.86 USP2 (0.47) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL6914295 0.85 USP2 (0.50) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL28983639 0.85 USP2 (0.44) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL16049616 0.84 USP2 (0.46) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL15368820 0.84 USP2 (0.49) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL18693555 0.83 USP2 (0.45) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL23329472 0.83 AOC2 (0.44) SMN1; SMN2EPHX2ALDH1A1TSHR
SCHEMBL15476186 0.82 USP2 (0.42) USP2SMN1; SMN2HPGDEPHX2TACR1
SCHEMBL1709866 0.82 USP2 (0.50) USP2SMN1; SMN2HPGDEPHX2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4076423-A1 TRPML MODULATORS Casma Therapeutics, Inc. (US) 2022-10-26 EP disclosed
CN-115087440-A TRPML modulators 卡斯玛治疗公司 2022-09-20 CN disclosed
WO-2021127337-A1 TRPML MODULATORS CASMA THERAPEUTICS, INC. (US) 2021-06-24 WO disclosed