Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25731609 | 0.75 | GPR119 (0.50) | GPR119 | |
| SCHEMBL29946091 | 0.75 | KDM4E (0.50) | GPR119 | |
| SCHEMBL3486718 | 0.74 | GPR119 (0.77) | GPR119 | |
| SCHEMBL20564764 | 0.73 | KDM4E (0.48) | GPR119 | |
| SCHEMBL23536418 | 0.73 | LIMK2 (0.46) | GPR119STSLIMK2 | |
| SCHEMBL23355023 | 0.72 | LIMK2 (0.53) | GPR119STSNPY2RLIMK2 | |
| SCHEMBL14191527 | 0.71 | GPR119 (0.52) | GPR119 | |
| SCHEMBL6109766 | 0.71 | SMN1; SMN2 (0.49) | GPR119NPY2RLIMK2 | |
| SCHEMBL13757780 | 0.71 | GPR119 (0.59) | GPR119LIMK2 | |
| SCHEMBL8024321 | 0.70 | GPR119 (0.46) | GPR119STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |