Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931872 | 1.00 | SLC18A3 (0.37) | SLC18A3SIGMAR1PDE4BALDH1A1L3MBTL1 | |
| SCHEMBL23555161 | 0.77 | SLC18A3 (0.38) | SLC18A3SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL29932028 | 0.74 | SLC6A4 (0.40) | SLC18A3SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL29932023 | 0.74 | KDM4E (0.40) | SLC18A3SIGMAR1SLC6A4KDM4E | |
| SCHEMBL29932037 | 0.72 | MCOLN2 (0.37) | ALDH1A1L3MBTL1KDM4EHTT | |
| SCHEMBL23558662 | 0.72 | AKT1 (0.43) | SLC18A3SIGMAR1PDE4BSLC6A4 | |
| SCHEMBL30232512 | 0.72 | AKT1 (0.43) | SLC18A3SIGMAR1PDE4BSLC6A4 | |
| SCHEMBL23555150 | 0.71 | SLC18A3 (0.39) | SLC18A3SIGMAR1OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL29931855 | 0.71 | AKT1 (0.42) | SLC18A3SIGMAR1PDE4BSLC6A4 | |
| SCHEMBL4253246 | 0.70 | HTR2A (0.36) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |