MCOLN2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL9253761	0.43	9/20
SCHEMBL8154192	0.50	8/20
SCHEMBL6305458	0.46	8/20
SCHEMBL6305460	0.46	8/20
SCHEMBL6303617	0.47	7/20
SCHEMBL6303621	0.47	7/20
SCHEMBL6311405	0.59	6/20
SCHEMBL6311411	0.59	6/20
SCHEMBL6307561	0.55	6/20
SCHEMBL6307563	0.55	6/20
SCHEMBL11603608	0.55	6/20
SCHEMBL11603611	0.55	6/20
SCHEMBL11603615	0.55	6/20
SCHEMBL6306235	0.51	6/20
SCHEMBL6306239	0.51	6/20
SCHEMBL11385108	0.50	6/20
SCHEMBL6303757	0.49	6/20
SCHEMBL6303763	0.49	6/20
SCHEMBL6310941	0.49	6/20
SCHEMBL6310948	0.49	6/20

Clinical trials — most relevant to MCOLN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety Study of a Gene Transfer Vector (Rh.10) for Children With Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL)	PHASE1	COMPLETED
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype	EARLY_PHASE1	COMPLETED
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML)	nan	WITHDRAWN
Mucolipidosis Type IV Natural History Study	nan	ACTIVE_NOT_RECRUITING
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease	nan	ENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases	nan	RECRUITING
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
An Observational Study in Children With CLN2 Batten Disease	nan	WITHDRAWN
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
A Natural History Study of Neuronal Ceroid Lipofuscinosis Type 5 (CLN5)	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis	nan	RECRUITING
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism	nan	COMPLETED
Molecular and Genetic Studies of Congenital Myopathies	nan	RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Nutritional Assessment in Mitochondrial Cytopathy	nan	COMPLETED
A Retrospective, Natural History Study in Children With CLN2	nan	WITHDRAWN
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Natural History of Neuronal Ceroid Lipofuscinosis, Batten's CLN6 Diseae	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a MCOLN2 binder may also engage these)

Protein	Name	Similarity
Q8K595	—	1.000	Q8K595 →
Q5YCC5	—	0.973	Q5YCC5 →
Q8C428	—	0.973	Q8C428 →
P0C152	—	0.973	P0C152 →
X1WEM4	—	0.971	X1WEM4 →
Q8R4P4	—	0.970	Q8R4P4 →
Q8BKU8	—	0.970	Q8BKU8 →
D3ZWZ9	—	0.970	D3ZWZ9 →
Q498T9	—	0.970	Q498T9 →
Q8BXN9	—	0.970	Q8BXN9 →
H2LRU7	—	0.970	H2LRU7 →
Q8NBN3	—	0.970	Q8NBN3 →
Q5DU41	—	0.969	Q5DU41 →
Q8R502	—	0.969	Q8R502 →
Q8BUV8	—	0.969	Q8BUV8 →
Q9TT17	—	0.969	Q9TT17 →
Q5HYA8	—	0.969	Q5HYA8 →
O42583	—	0.969	O42583 →
Q6IVV8	—	0.969	Q6IVV8 →
Q8TDI7	—	0.969	Q8TDI7 →
Q5VW38	—	0.968	Q5VW38 →
A5PK13	—	0.968	A5PK13 →
Q68F79	—	0.968	Q68F79 →
F6RG56	—	0.968	F6RG56 →
Q6P9F7	—	0.968	Q6P9F7 →
Q96K49	—	0.968	Q96K49 →
Q32NZ6	—	0.968	Q32NZ6 →
Q148L1	—	0.968	Q148L1 →
Q91WD0	—	0.968	Q91WD0 →
TRPM6	Transient receptor potential cation channel subfamily M member 6	0.968	landscape →