Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 4/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536660 | 0.84 | PDE4A (0.39) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536763 | 0.84 | HTR6 (0.40) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536610 | 0.84 | HTR6 (0.36) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536640 | 0.80 | HTR6 (0.35) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536836 | 0.80 | HTR6 (0.35) | HTR6PDE4AKLK7 | |
| SCHEMBL23536717 | 0.78 | HTR6 (0.37) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536696 | 0.78 | HTR6 (0.35) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536573 | 0.77 | HTR6 (0.33) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23536759 | 0.77 | HTR6 (0.33) | HTR6PDE4AKLK7PTGDR2PTGDR | |
| SCHEMBL23570036 | 0.75 | PDE4A (0.36) | HTR6PDE4AKLK7PTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |