Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536715 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL13721338 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL14875548 | 0.81 | LRRK2 (0.43) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL30232329 | 0.81 | KDM4E (0.39) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL30232521 | 0.79 | PARP1 (0.38) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL31602573 | 0.77 | LRRK2 (0.39) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL10535470 | 0.77 | KMT2A (0.63) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL16025726 | 0.74 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL3067812 | 0.74 | HPGD (0.55) | ALDH1A1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL18228562 | 0.74 | HPGD (0.55) | ALDH1A1MEN1KMT2AMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |