Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880914 | 0.85 | MAOB (0.48) | MAOBNR4A2MRGPRX4FFAR1FFAR4 | |
| SCHEMBL18740137 | 0.85 | MAOB (0.48) | MAOBNR4A2MRGPRX4FFAR1FFAR4 | |
| SCHEMBL5764984 | 0.85 | NR4A2 (0.50) | MAOBNR4A2MRGPRX4LMNACYP1A2 | |
| SCHEMBL17048583 | 0.84 | PSEN1 (0.48) | MAOBNR4A2PSEN1PSEN2APH1B | |
| SCHEMBL13753986 | 0.84 | MAOB (0.59) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL21958646 | 0.83 | GRM5 (0.51) | MAOBNR4A2PSEN1PSEN2APH1B | |
| SCHEMBL23536844 | 0.82 | MAOB (0.61) | MAOBNR4A2FFAR1FFAR4MAPT | |
| SCHEMBL23536653 | 0.82 | POLB (0.48) | MAOBNR4A2MRGPRX4BCHEFFAR1 | |
| SCHEMBL21026818 | 0.82 | MAOB (0.58) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL21263202 | 0.82 | MAOB (0.58) | MAOBLMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |