Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943499 | 0.85 | MEN1 (0.59) | MAPTNR4A2MAOBMAOAMEN1 | |
| SCHEMBL5766322 | 0.83 | MAOA (0.60) | POLBMAPTNR4A2MRGPRX4MAOB | |
| SCHEMBL15880914 | 0.82 | MAOB (0.48) | NR4A2MRGPRX4MAOBFFAR1FFAR4 | |
| SCHEMBL5764984 | 0.82 | NR4A2 (0.50) | NR4A2MRGPRX4MAOBFFAR1FFAR4 | |
| SCHEMBL23536709 | 0.82 | MAOB (0.48) | MAPTNR4A2MRGPRX4MAOBFFAR1 | |
| SCHEMBL18740137 | 0.82 | MAOB (0.48) | NR4A2MRGPRX4MAOBFFAR1FFAR4 | |
| SCHEMBL136463 | 0.82 | RXRA (0.56) | NR4A2MRGPRX4MAOBFFAR1FFAR4 | |
| SCHEMBL18003540 | 0.80 | MAOB (0.60) | POLBMAPTNR4A2MRGPRX4MAOB | |
| SCHEMBL23536844 | 0.80 | MAOB (0.61) | MAPTNR4A2MAOBMAOAFFAR1 | |
| SCHEMBL27799862 | 0.80 | FFAR1 (0.67) | NR4A2MRGPRX4FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |