Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 10/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | C1S | P09871 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30493134 | 0.82 | SOS1 (0.51) | KHKADRB1C1SHTR6MAPT | |
| SCHEMBL30014316 | 0.77 | KHK (0.45) | KHKADRB1HRH4HTR6HTR3E | |
| SCHEMBL5097183 | 0.73 | KHK (0.54) | KHKADRB1HTR6HTR3EHTR3B | |
| SCHEMBL30014605 | 0.71 | C1S (0.54) | ADRB1KCNH2C1SMAPTRECQL | |
| SCHEMBL26769201 | 0.70 | MAPT (0.52) | KHKADRB1HTR6MAPTRECQL | |
| SCHEMBL7256928 | 0.69 | FGFR1 (0.53) | KHKADRB1HTR6MAPTRECQL | |
| SCHEMBL2547737 | 0.68 | KHK (1.00) | KHK | |
| SCHEMBL682499 | 0.68 | KHK (0.63) | KHK | |
| SCHEMBL15244955 | 0.67 | ADRB1 (0.51) | KHKADRB1HTR6MAPTHTR3E | |
| SCHEMBL30775562 | 0.67 | IP6K1 (0.76) | ADRB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |