Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30265199 | 0.90 | HTT (0.71) | HTTPOLBTDP1L3MBTL1LMNA | |
| SCHEMBL2354324 | 0.89 | HTT (0.54) | HTTPOLBTDP1HPGDTP53 | |
| SCHEMBL1534628 | 0.88 | HTT (0.52) | HTTPOLBTDP1L3MBTL1LMNA | |
| SCHEMBL30265457 | 0.86 | HTT (0.51) | HTTPOLBTDP1HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2355781 | 0.85 | HTT (0.50) | HTTPOLBTDP1HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL17802677 | 0.85 | HTT (0.50) | HTTPOLBTDP1HPGDL3MBTL1 | |
| SCHEMBL396107 | 0.85 | POLB (0.53) | HTTPOLBTDP1HPGDL3MBTL1 | |
| SCHEMBL2351821 | 0.85 | HTT (0.57) | HTTPOLBTDP1HPGDTP53 | |
| SCHEMBL13373316 | 0.84 | HTT (0.57) | HTTPOLBTDP1HPGDL3MBTL1 | |
| SCHEMBL2350429 | 0.84 | HTT (0.56) | HTTPOLBTDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| WO-2011103018-A1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-08-25 | — | — | WO | disclosed |