Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538279 | 0.84 | — | — | |
| SCHEMBL23538235 | 0.77 | TUBB1 (0.55) | MAPTMEN1KMT2ANR4A2TUBB1 | |
| SCHEMBL23551352 | 0.75 | MEN1 (0.65) | MAPTMEN1KMT2ANR4A2NPC1 | |
| SCHEMBL23538127 | 0.74 | MEN1 (0.54) | MAPTMEN1KMT2ANR4A2TUBB1 | |
| SCHEMBL23538286 | 0.70 | ALDH1A1 (0.48) | MAPT | |
| SCHEMBL23538056 | 0.67 | NPC1 (0.49) | MAPTMEN1KMT2ANR4A2TUBB1 | |
| SCHEMBL22644112 | 0.64 | MEN1 (0.66) | MAPTMEN1KMT2ANR4A2NPC1 | |
| SCHEMBL23538300 | 0.64 | KMT2A (0.62) | MAPTMEN1KMT2ANR4A2CREBBP | |
| SCHEMBL23551126 | 0.64 | MEN1 (0.62) | MAPTMEN1KMT2ANR4A2NPC1 | |
| SCHEMBL23551200 | 0.63 | KMT2A (0.65) | MAPTMEN1KMT2ANR4A2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127302-A1 | 2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |