Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539472 | 0.85 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539511 | 0.85 | TSHR (0.70) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23540142 | 0.85 | ALDH1A1 (0.67) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23540217 | 0.84 | TSHR (0.67) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539492 | 0.83 | ALDH1A1 (0.67) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539161 | 0.82 | TSHR (0.66) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539148 | 0.82 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539473 | 0.82 | ALDH1A1 (0.66) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539176 | 0.82 | TSHR (0.65) | ALDH1A1TSHRLMNAMAPTUSP2 | |
| SCHEMBL23539300 | 0.80 | ALDH1A1 (0.70) | ALDH1A1TSHRLMNAMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127328-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |