Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12816594 | 0.84 | OPRK1 (0.45) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL1445254 | 0.83 | OPRK1 (0.45) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL7932045 | 0.82 | OPRK1 (0.46) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL24338284 | 0.82 | GLA (0.41) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL22213479 | 0.81 | OPRK1 (0.45) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL1226725 | 0.81 | SMN1; SMN2 (0.44) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL1227266 | 0.81 | SMN1; SMN2 (0.44) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL1226722 | 0.81 | SMN1; SMN2 (0.44) | OPRK1HTR2CHTR1AADORA3SLC6A3 | |
| SCHEMBL27254036 | 0.81 | HTR2C (0.47) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL26983226 | 0.80 | HTR2C (0.46) | HTR2CNPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |
| WO-2021127404-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2021-06-24 | — | — | WO | disclosed |