Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23545062 | 1.00 | HRH3 (0.33) | HRH3IL1BCHRM2CHRM4KDM1A | |
| SCHEMBL20936804 | 1.00 | HRH3 (0.33) | HRH3IL1BCHRM2CHRM4KDM1A | |
| SCHEMBL20936943 | 1.00 | HRH3 (0.33) | HRH3IL1BCHRM2CHRM4KDM1A | |
| SCHEMBL20936982 | 0.81 | ALDH1A1 (0.42) | HRH3IL1BJAK2JAK1 | |
| SCHEMBL23545106 | 0.81 | ALDH1A1 (0.42) | HRH3IL1BJAK2JAK1 | |
| SCHEMBL29919345 | 0.81 | ALDH1A1 (0.42) | HRH3IL1BJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL23523614 | 0.79 | ALDH1A1 (0.41) | HRH3IL1BJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL31119102 | 0.79 | ALDH1A1 (0.41) | HRH3IL1BJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL23523613 | 0.79 | ALDH1A1 (0.41) | HRH3IL1BJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL23523611 | 0.79 | ALDH1A1 (0.41) | HRH3IL1BJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820757-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2023-11-21 | — | — | US | disclosed |
| US-20220213069-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2022-07-07 | — | — | US | disclosed |
| US-11299481-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2022-04-12 | — | — | US | disclosed |
| US-20210188820-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11820757-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | CHRM2, CHRM3, CHRM4 | HRH3 87/4885IL1B 4692/4885CHRM2 1/4885 |
| US-11299481-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | CHRM2, CHRM3, CHRM4 | HRH3 87/4885IL1B 4692/4885CHRM2 1/4885 |
| US-20220213069-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM2, CHRM3, CHRM4 | HRH3 87/4885IL1B 4692/4885CHRM2 1/4885 |
| US-20210188820-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM2, CHRM3, CHRM4 | HRH3 87/4885IL1B 4692/4885CHRM2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.