Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757856 | 1.00 | LMNA (0.31) | LMNAMAPTPOLB | |
| SCHEMBL15320374 | 0.83 | POLB (0.32) | POLB | |
| SCHEMBL104499 | 0.81 | LMNA (0.42) | LMNAMAPTPOLB | |
| SCHEMBL19331934 | 0.81 | LMNA (0.32) | LMNAMAPTPOLB | |
| SCHEMBL19716095 | 0.80 | LMNA (0.31) | LMNAMAPTPOLB | |
| SCHEMBL17868701 | 0.78 | — | — | |
| SCHEMBL2487318 | 0.75 | LMNA (0.34) | LMNAMAPTPOLB | |
| SCHEMBL21528223 | 0.75 | — | — | |
| SCHEMBL20163725 | 0.74 | ABCB1 (0.33) | POLB | |
| SCHEMBL18979169 | 0.73 | LMNA (0.34) | LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046686-B2 | Thiadiazole IRAK4 compounds | GILEAD SCIENCES, INC. (US) | 2021-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046686-B2 | Thiadiazole IRAK4 compounds | IRAK4, IRAK3, IRAK2 | LMNA 2962/4885MAPT 1995/4885POLB 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.