SCHEMBL2355138

SCHEMBL2355138

COc1c(O)cc2c(=O)oc3c(O)c(O)cc4c(=O)oc1c2c34

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.88
MEN1 O00255 4/20 0.88
MAPT P10636 4/20 0.88
HPGD P15428 4/20 0.88
RECQL P46063 4/20 0.88
BLM P54132 4/20 0.88
KMT2A Q03164 4/20 0.88
APEX1 P27695 2/20 0.88
TDP1 Q9NUW8 2/20 0.88
ALDH1A1 P00352 2/20 0.88
RELA Q04206 1/20 0.76
MAOA P21397 5/20 0.72
HSD17B10 Q99714 3/20 0.72
CA12 O43570 2/20 0.72
CA1 P00915 2/20 0.72
CA7 P43166 2/20 0.72
CA9 Q16790 2/20 0.72
CA13 Q8N1Q1 2/20 0.72
TP53 P04637 2/20 0.72
THRB P10828 2/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508368 0.94 KDM4E (1.00) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL941032 0.94 KDM4E (1.00) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL38658338 0.90 CA12 (0.84) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL13805434 0.90 KDM4E (0.80) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL940860 0.90 CA12 (0.84) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL2369012 0.87 KDM4E (0.77) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL30608638 0.86 RELA (1.00) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL941424 0.86 RELA (1.00) KDM4EMEN1MAPTHPGDRECQL
SCHEMBL16401447 0.86 KDM4E (0.65) KDM4EMEN1MAPTHPGDRECQL
Ellagic Acid SCHEMBL28824363 0.85 KDM4E (0.92) KDM4EMEN1MAPTHPGDRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023128710-A1 TABLET CONTAINING MIXED EXTRACT OF CINNAMOMI RAMULUS AND MOUTAN RADICIS CORTEX AS ACTIVE INGREDIENT AND COMPOSITION DESIGNED TO ADMINISTER SPECIFIC DOSAGE THEREOF FOR TREATMENT 주식회사 큐라클 2023-07-06 WO claimed
CN-113264975-B An extract with antiinflammatory activity extracted from fructus Rosae Normalis rhizome and its application 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2023-10-20 CN disclosed
WO-2023128710-A1 TABLET CONTAINING MIXED EXTRACT OF CINNAMOMI RAMULUS AND MOUTAN RADICIS CORTEX AS ACTIVE INGREDIENT AND COMPOSITION DESIGNED TO ADMINISTER SPECIFIC DOSAGE THEREOF FOR TREATMENT 주식회사 큐라클 2023-07-06 WO disclosed
CN-109765320-B Content determination method for tendon and bone injury spraying agent 贵州远程制药有限责任公司 2022-03-22 CN disclosed
WO-2021106856-A1 COMPOSITION FOR IMPROVING URINARY TRACT FUNCTION AND COMPOSITION FOR IMPROVING BLOOD FLOW IN BLADDER 小林製薬株式会社 2021-06-03 WO disclosed
WO-2021106857-A1 COMPOSITION FOR PREVENTING OR RELIEVING URESIESTHESIA STRESS, AND COMPOSITION FOR IMPROVING SLEEP 小林製薬株式会社 2021-06-03 WO disclosed
CN-109984975-A With the Preparation method and use of antioxidant activity total phenol in a kind of apocarya grouts 江苏省中国科学院植物研究所 2019-07-09 CN disclosed
CN-109765320-A A kind of content assaying method for spray agent for treating tendon and bone injury 贵州远程制药有限责任公司 2019-05-17 CN disclosed
CN-105837645-B The method that 3- methoxyl group ellagic acid -4-O- β-D-Glucose glycosides is extracted from Camellia Leaves 中南林业科技大学 2018-08-28 CN disclosed
CN-106259549-B Air purification composition 王婧宁 2017-05-17 CN disclosed
CN-1266421-B Anticancer compounds PEPLIN PTY LTD 2014-06-18 CN disclosed
WO-2011098818-A1 DIETARY SUPPLEMENT COMPOSITION GOMEZ, RIGEL (PH) 2011-08-18 WO disclosed
WO-2011094708-A2 SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATIING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS DANA-FARBER CANCER INSTITUTE, INC (US) 2011-08-04 WO disclosed
WO-2004064725-A2 ORAL COMPOSITIONS AND METHODS FOR TREATMENT OF ADVERSE EFFECTS OR RADIATION THE QUIGLEY CORPORATION (US) 2004-08-05 WO disclosed
CN-1119144-C Composition for external application LION CORP (JP) 2003-08-27 CN disclosed
EP-1289489-A2 TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE PENTAPHARM Ltd. (CH) 2003-03-12 EP disclosed
WO-2001091715-A2 TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE PENTAPHARM LTD. (CH) 2001-12-06 WO disclosed
CN-1266421-A Anticancer compounds PEPLIN PTY LTD (AU) 2000-09-13 CN disclosed
CN-1187990-A Composition for external application LION CORP (JP) 1998-07-22 CN disclosed