Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355195 | 1.00 | MAPT (0.46) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2223782 | 0.82 | OPRK1 (0.51) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2224394 | 0.81 | MAPT (0.46) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2224463 | 0.81 | MAPT (0.46) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2224263 | 0.78 | MAPT (0.58) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL14653745 | 0.76 | MAPT (0.57) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2224395 | 0.76 | MAPT (0.59) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL2223761 | 0.76 | MAPT (0.59) | MAPTLMNAKDM4EPOLBNPSR1 | |
| Hydrochloric Acid SCHEMBL2226941 | 0.75 | MAPT (0.58) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL12516105 | 0.75 | MAPT (0.60) | MAPTLMNAKDM4EPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |