Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25961547 | 0.86 | GAA (0.54) | HSD17B10SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL23553767 | 0.85 | KMT2A (0.60) | HSD17B10SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL20939066 | 0.82 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL20939158 | 0.80 | HSD17B10 (0.44) | HSD17B10SMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL20857568 | 0.80 | DPP4 (0.46) | HSD17B10SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL23553276 | 0.80 | DPP4 (0.48) | MEN1KMT2ADPP4ALDH1A1TSHR | |
| SCHEMBL20468901 | 0.78 | DPP4 (0.43) | HSD17B10SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL3272489 | 0.76 | CYP3A4 (0.47) | HSD17B10KMT2AKDM5ACYP3A4RAB9A | |
| SCHEMBL2645027 | 0.75 | DPP4 (0.47) | SMN1; SMN2MEN1KMT2ARAB9AGAA | |
| SCHEMBL30920935 | 0.75 | DPP4 (0.47) | SMN1; SMN2MEN1KMT2ARAB9ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127586-A1 | PROTEIN TYROSINE PHOSPHATASE DEGRADERS AND METHODS OF USE THEREOF | CALICO LIFE SCIENCES LLC (US) | 2021-06-24 | — | — | WO | disclosed |