Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | CFTR | P13569 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | IDH2 | P48735 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539338 | 0.91 | VCP (0.67) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23554236 | 0.91 | VCP (0.72) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23691136 | 0.89 | VCP (0.61) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23553605 | 0.88 | VCP (0.65) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL26308537 | 0.88 | VCP (0.60) | VCPMAPTMAPK1KDM4ENPSR1 | |
| Bromide SCHEMBL1203805 | 0.87 | VCP (0.64) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL12157929 | 0.87 | VCP (0.67) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23539994 | 0.86 | MAPT (0.65) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23539816 | 0.86 | VCP (0.65) | VCPMAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL23553606 | 0.86 | VCP (0.65) | VCPMAPTMAPK1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127301-A1 | 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |