Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23530030 | 0.77 | CFTR (0.37) | PDE1APDE1BPDE1C | |
| SCHEMBL23529995 | 0.76 | CCR1 (0.38) | CCR1PDE1APDE1BPDE1CCHRM1 | |
| SCHEMBL23554315 | 0.76 | DGKZ (0.32) | PDE1APDE1BPDE1C | |
| SCHEMBL29549913 | 0.74 | PTGER4 (0.42) | PDE1APDE1BPDE1C | |
| SCHEMBL23529922 | 0.74 | PTGER4 (0.42) | PDE1APDE1BPDE1C | |
| SCHEMBL23554620 | 0.72 | PDE1B (0.34) | CCR1PDE1APDE1BPDE1C | |
| SCHEMBL23530084 | 0.71 | PDE1A (0.39) | PDE1APDE1BPDE1C | |
| SCHEMBL15339576 | 0.67 | KDM4E (0.39) | BRD4BRD2BRD3PDE1BPDE1C | |
| SCHEMBL26098592 | 0.66 | PTGER4 (0.39) | BRD4PDE1APDE1BPDE1C | |
| SCHEMBL23535643 | 0.65 | MAPT (0.41) | BRD4BRD2BRD3PDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021121294-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2021-06-24 | — | — | WO | disclosed |