DGKZ — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21830819	1.00	20/20
SCHEMBL21830910	1.00	20/20
SCHEMBL21830979	1.00	20/20
SCHEMBL21831056	1.00	20/20
SCHEMBL21831058	1.00	20/20
SCHEMBL21831090	1.00	20/20
SCHEMBL21831135	1.00	20/20
SCHEMBL21831255	1.00	20/20
SCHEMBL21831258	1.00	20/20
SCHEMBL21831277	1.00	20/20
SCHEMBL21831347	1.00	20/20
SCHEMBL21831344	0.95	20/20
SCHEMBL21831210	0.94	20/20
SCHEMBL21830895	0.93	20/20
SCHEMBL21830901	0.93	20/20
SCHEMBL21830905	0.93	20/20
SCHEMBL21831350	0.93	20/20
SCHEMBL21831423	0.93	20/20
SCHEMBL21831234	0.92	20/20
SCHEMBL21831059	0.91	20/20

Clinical trials — most relevant to DGKZ by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)	PHASE2	COMPLETED
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Tissue Lipids and Insulin Resistance	nan	WITHDRAWN
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer	nan	COMPLETED
Effects of Obesity and Intensity of Exercise on Ghrelin Levels	nan	COMPLETED
Study of Changes in Skeletal Muscle After Caloric Restriction	nan	ACTIVE_NOT_RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DGKZ binder may also engage these)

Protein	Name	Similarity
O08560	—	1.000	O08560 →
Q80UP3	—	1.000	Q80UP3 →
D3YWQ0	—	1.000	D3YWQ0 →
F1MAB7	—	0.996	F1MAB7 →
DGKI	Diacylglycerol kinase iota	0.995	landscape →
D3ZEY4	—	0.993	D3ZEY4 →
Q39017	—	0.992	Q39017 →
Q6P5E8	—	0.990	Q6P5E8 →
Q03603	—	0.990	Q03603 →
A3KMV1	—	0.989	A3KMV1 →
Q9FFN7	—	0.989	Q9FFN7 →
KAT8	Histone acetyltransferase KAT8	0.989	landscape →
Q8TBC3	—	0.989	Q8TBC3 →
Q10024	—	0.988	Q10024 →
P49620	—	0.988	P49620 →
DGKG	Diacylglycerol kinase gamma	0.988	landscape →
Q5XI06	—	0.987	Q5XI06 →
Q28314	—	0.987	Q28314 →
Q8BJM7	—	0.987	Q8BJM7 →
NFKB1	Nuclear factor NF-kappa-B p105 subunit	0.987	landscape →
Q6ZPS6	—	0.987	Q6ZPS6 →
Q8TDY4	—	0.987	Q8TDY4 →
G5EFD2	—	0.987	G5EFD2 →
KDM1A	Lysine-specific histone demethylase 1A	0.987	landscape →
Q91WG7	—	0.987	Q91WG7 →
Q9LRB0	—	0.987	Q9LRB0 →
KDM5B	Lysine-specific demethylase 5B	0.987	landscape →
E9PUQ8	—	0.986	E9PUQ8 →
P54310	—	0.986	P54310 →
KDM4B	Lysine-specific demethylase 4B	0.986	landscape →